研究

Within the Clinical Genomics and Advanced Technologies (CGAT) laboratory, the goals of department-wide research initiatives are:

  • Provide state-of-the-art diagnostic services to support our providers 和病人
  • Engage in and support cutting-edge research that will translate to novel diagnostic and therapeutic strategies for our patients
  • Provide educational opportunities in the genomics space at all levels.

We oversee the following collaborative research resource programs:

E.D.I.T. (Emerging Diagnostic and Investigative Technologies) Program

This integrated and collaborative program houses innovative diagnostic technologies for projects spanning these four fields:

  • Machine learning and computational diagnostic pathology: Using artificial intelligence and digital sciences to implement and commercialize enhanced algorithms designed to remove subjectivity from the analysis of clinical data and to provide concrete, statistically driven recommendations to researchers, 临床医生, 和病人
  • 生物标志物的发现: Identifying novel pathways and biomarkers for faster diagnosis of disease, 精细化疾病分类, and better monitoring of disease progression
  • 先进的辅助测试: Developing and evaluating advanced technologies for research applications that can translate to clinical practice (examples: digital spatial profiling, CRISPR, STAT molecular testing and mass spectroscopy)
  • 基因组医学: Expanding population health studies regionally, nationally and globally (examples NCI-MATCH, 体重与健康计划, 洪都拉斯, 科索沃, 卢旺达)

Pathology Translational 研究 Shared Resource (PSR)

This is a designated 十大博彩推荐排名癌症中心 Shared Resource facility, created to provide investigators access to the following in a CLIA-licensed, CAP-accredited laboratory environment:

  • 生物
  • 生物标志物检测
  • 细胞治疗服务
  • Latest technologies for genomic studies

The PSR has dedicated staff for tissue preparation, 处理, 以及动物组织的染色, 细胞培养, 人体组织.

Immunohistochemistry (IHC) for routine antibodies or the validation of new antibodies (including fluorescent-labeled antibody staining) is offered.

Multiplex double-staining techniques for nucleic acids and proteins along with the creation of tissue arrays are also available.

Investigators have access to more than 25 subspecialty pathologists who can assist in experimental design, 组织选择, 并进行解释.

Learn more about the Pathology Shared Resource (PSR)

细胞治疗中心(CTC)

The 细胞治疗中心(CTC) supports the technical needs of projects related to bone marrow transplantation and cancer immunotherapy with cell-based therapies.

由 兹比格涅夫•米. szczeporkowski，医学博士，博士, the CTC is a GMP facility that isolates, 净化, 操纵, 扩展, and/or stores cells derived from a patient's/subject's peripheral blood and/or bone marrow and intended for autologous reinfusion.

To ensure patient safety and to meet all current and expected FDA Investigational New Drug (IND) requirements and (future) product licensure requirements, the CTC operates in compliance with the FDA's current Good Manufacturing Practices (GMP), using personnel and techniques that meet all CLIA-88 requirements for clinical laboratories.

The physical space of the CTC has been expanded to allow accommodation of negative pressure rooms that would allow for the use of lentivirus-based vectors and studies of chimeric antigen receptor (CAR)-modified cells.

机构生物库(IBR)

The Pathology Department has developed the infrastructure for collection, 处理, 存储, and distribution of annotated human bio-specimens to 临床医生 and other investigators in support of clinical trials, 参加的项目, 以及科学调查.

The 机构生物库(IBR) has banked a variety of tissue/specimen types and extracted nucleic acids.

所有生物标本处理, 处理, 存储是标准化的, with established operating procedures, in accordance with the College of American Pathologists regulatory Bio-repository checklist.

Transfusion Medicine 研究 Center

The Transfusion Medicine 研究 Center participates in proof-of-concept and pre-FDA licensure Phase I/II clinical trials for transfusion medicine related products and processes. Radioactive recovery and survival studies are special areas of interest. The center can also function as a reference laboratory for other research laboratories.